Karnak® Ultimate

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KARNAK® technology is patented and based on published scientific studies


The patented KARNAK® technology, used in all lines of devices, is based both on the consolidated scientific bibliography published in the field of PEMF and LLLT and on the studies and research of Nobel Prize winners and internationally renowned scientists such as W.K. Heisenberg, Max Planck, Carlo Rubbia, C.A. Bassett, R.J. Pawluk, F.A. Popp, Ernst Chladni and Thomas Young. 


Some of the main literature sources that examine in depth the concepts of Applied Physics in Medicine:

Medicina Quantistica - La medicina attraverso la fisica dei quanti - third edition
Dott. Piergiorgio Spaggiari, Dott.ssa Caterina Tribbia
2016 Tecniche Nuove


Terapia Ambulatoriale e domiciliare con risonanza magnetica Dott. Fabio Petrossi
2002 Italo Svevo


Some of the major bibliographic sources are listed:
Impulse Magnetic-Field Therapy for Insomnia: A Double-Blind, Placebo-Controlled Study Rainer B. Pelka, Ph.D. Universität der Bundeswehr München Neubiberg/Munich, Germany Christof Jaenicke, M.D., Joerg Gruenwald, Ph.D. PhytoPharm Consulting Institute for Phytopharmaceuticals Berlin,  Germany 

2001 Advances In Therapy 


Repetitive transcranial magnetic stimulation as an augmentative strategy for treatment-resistant  depression, a meta-analysis of randomized, double-blind and sham-controlled study Liu B, Zhang Y, Zhang L, Li L. 

BMC Psychiatry 2014 


Effectiveness and acceptability of accelerated repetitive transcranial magnetic stimulation (rTMS) for  treatment-resistant major depressive disorder: an open label trial 

McGirr A , Van den Eynde F , Tovar-Perdomo S , Fleck MP , Berlim MT 

2014 Elsevier B.V. 


Inhibition of Angiogenesis Mediated by Extremely Low- Frequency Magnetic Fields (ELF-MFs) Simona Delle Monache, Adriano Angelucci, Patrizia Sanità, Roberto Iorio, Francesca Bennato, Fabrizio Mancini,  Giancaterino Gualtieri, Rosella Cardigno Colonna 

2013 Irina V. Lebedeva, Columbia University, United States of America 


rTMS in fibromyalgia: a randomized trial evaluating QoL and its brain metabolic substrate Boyer L., Dousset A., Roussel P., Dossetto N., Cammilleri S., Piano V., Khalfa S., Mundler O., Donnet A., Guedj E. 2014 American Academy of Neurology. 


Long-term maintenance of the analgesic effects of transcranial magnetic stimulation in fibromyalgia Mhalla A , Baudic S, Ciampi de Andrade D, Gautron M, Perrot S, Teixeira MJ, Attal N, Bouhassira D. 2011 Published by Elsevier B.V. 


Priming Stimulation Enhances the Effectiveness of Low-Frequency Right Prefrontal Cortex Transcranial  Magnetic Stimulation in Major Depression 

Paul B. Fitzgerald, MBBS, MPM, PhD, FRANZCP, Kate Hoy, BBNSc (Hons), Susan McQueen, RN, RPN (Nursing), Sally  Herring, BA (Hons), Rebecca Segrave, BSci (Hons), Greg Been, MBBS, Jayashri Kulkarni, MBBS, MPM, PhD, FRANZCP,  and Zafiris J. Daskalakis, MD, PhD, FRCP(C) 

Journal of Clinical Psychopharmacology 2008 


The efficacy and safety of low frequency repetitive transcranial magnetic stimulation for treatment resistant depression: the results from a large multicenter French RCT. 

Brunelin J , Jalenques I , Trojak B , Attal J , Szekely D , Gay A , Januel D , Haffen E , Schott-Pethelaz AM , Brault C ; STEP 

Group, Poulet E . 

2014 Elsevier Inc. 


Neurophysiological predictors of non-response to rTMS in depression 

Martijn Arns, Wilhelmus H. Drinkenburg, Paul B. Fitzgerald, J. Leon Kenemans 

2012 Elsevier Inc. 


Repetitive Transcranial Magnetic Stimulation in Chronic Pain: A Review of the Literature. Galhardoni R , Correia GS , Araujo H , Yeng LT , Fernandes DT , Kaziyama HH , Marcolin MA , Bouhassira D , Teixeira MJ,  de Andrade DC . 

2015 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. 


Therapeutic applications of repetitive transcranial magnetic stimulation (rTMS) in movement disorders: A  review 

Nitish Kamble, M. Netravathi, Pramod Kumar Pal 

Department of Neurology, National Institute of Mental Health & Neurosciences (NIMHANS), Hosur Road, Bangalore  560029, Karnataka, India 

2014 Published by Elsevier Ltd 


Non-invasive Brain Stimulation for Essential Tremor 

Ludy C. Shih & Alvaro Pascual-Leone 

2017 Elan D. Louis, Yale University, USA 


Modulation of Osteogenesis in Human Mesenchymal Stem Cells by Specific Pulsed Electromagnetic Field  Stimulation 

Ming-Tzu Tsai, Wan-Ju Li, Rocky S. Tuan, and Walter H. Chang 

2009 J Orthop Res. 


Effect of Pulse-Burst Electromagnetic Field Stimulation on Osteoblast Cell Activities Walter Hong-Shong Chang, Li-Ting Chen, Jui-Sheng Sun, and Feng-Huei Lin 

Published on 2003 in Wiley InterScience 


Effect of Pulsed Electromagnetic Field on the Proliferation and Differentiation Potential of Human Bone  Marrow Mesenchymal Stem Cells 

Li-Yi Sun, Dean-Kuo Hsieh, Tzai-Chiu Yu, Hsien-Tai Chiu, Sheng-Fen Lu, Geng-Hong Luo, Tom K. Kuo, Oscar K.  Lee, and Tzyy-Wen Chiou 

Published on 2009 in Wiley InterScience 


Pulsed electromagnetic fields influence hyaline cartilage extracellular matrix composition without  affecting molecular structure 


1996 Osteoarthritis and Cartilage 


Smoking Cessation Induced by Deep Repetitive Transcranial Magnetic Stimulation of the Prefrontal and  Insular Cortices: A Prospective, Randomized Controlled Trial 

Limor Dinur-Klein, Pinhas Dannon, Aviad Hadar, Oded Rosenberg, Yiftach Roth, Moshe Kotler, and Abraham Zangen BIOL PSYCHIATRY 2014 


Evaluation of acute effect of light-emitting diode (LED) phototherapy on muscle deoxygenation and  pulmonary oxygen uptake kinetics in patients with diabetes mellitus: study protocol for a randomized  controlled trial 

Cristina de Oliveira Francisco, Thomas Beltrame, Cleber Ferraresi, Nivaldo Antonio Parizotto, Vanderlei Salvador  Bagnato, Audrey Borghi Silva, Benedito Galvão Benze, Alberto Porta and Aparecida Maria Catai Francisco et al. Trials 2015


Light-emitting diode therapy (LEDT) before matches prevents increase in creatine kinase with a light dose  response in volleyball players 

Cleber Ferraresi & Ricardo Vinicius dos Santos & Guilherme Marques & Marcelo Zangrande & Roberley Leonaldo &  Michael R. Hamblin & Vanderlei Salvador Bagnato & Nivaldo Antonio Parizotto 

Springer-Verlag London 2015 


Low-level laser (light) therapy increases mitochondrial membrane potential and ATP synthesis in C2C12  myotubes with a peak response at 3-6 hours 

Cleber Ferraresi, Beatriz Kaippert, Pinar Avci, Ying-Ying Huang, Marcelo Victor Pires de Sousa, Vanderlei Salvador  Bagnato, Nivaldo Antonio Parizotto, and Michael R Hamblin 

Photochem Photobiol. Author manuscript; available in PMC 2016 


Muscular pre-conditioning using light-emitting diode therapy (LEDT) for high-intensity exercise: a  randomized double-blind placebo-controlled trial with a single elite runner 

Cleber Ferraresi, PhD, Thomas Beltrame, MSc, Fernando Fabrizzi, MSc, Eduardo Sanches Pereira do Nascimento, PhD,  Marlus Karsten, PhD, Cristina de Oliveira Francisco, MSc, Audrey Borghi-Silva, PhD, Aparecida Maria Catai, PhD5,  Daniel Rodrigues Cardoso, PhD, Antonio Gilberto Ferreira, PhD, Michael R. Hamblin, PhD, Vanderlei Salvador Bagnato,  PhD, and Nivaldo Antonio Parizotto, PhD 

2015 Informa Healthcare USA, Inc 


Shining light on the head: Photobiomodulation for brain disorders 

Michael R. Hamblin 

2016 Published by Elsevier B.V. 


Photobiomodulation with Near Infrared Light Helmet in a Pilot, Placebo Controlled Clinical Trial in  Dementia patients Testing Memmory and Cognition 

Marvin H Berman, James P Halper, Trent W Nichols, Jarrett H, Alan Lundy and Jason H Huang 2017 Journal of Neurology and Neuroscience.

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